SrasV1, Main, Exploration, bibRecord, 004E35

Effects of severe acute respiratory syndrome (SARS) coronavirus infection on peripheral blood lymphocytes and their subsets

Identifieur interne : 004E35 ( Main/Exploration ); précédent : 004E34; suivant : 004E36

Effects of severe acute respiratory syndrome (SARS) coronavirus infection on peripheral blood lymphocytes and their subsets

Auteurs : ZHONGPING HE [République populaire de Chine] ; CHUNHUI ZHAO [République populaire de Chine] ; QINGMING DONG [République populaire de Chine] ; HUI ZHUANG [République populaire de Chine] ; SHUJING SONG [République populaire de Chine] ; GUOAI PENG [République populaire de Chine] ; Dominic E. Dwyer [Australie]

Source :

International journal of infectious diseases [ 1201-9712 ] ; 2005.

RBID : Pascal:05-0496221

Descripteurs français

Pascal (Inist)
- Syndrome respiratoire aigu sévère, Bactériémie, Lymphopénie, Sous population cellulaire, Lymphocyte, Coronavirus, Antigène CD4, Antigène CD8.

English descriptors

KwdEn :
- Bacteremia, Cell subpopulation, Coronavirus, Lymphocyte, Lymphocytopenia, Severe acute respiratory syndrome.

Abstract

Introduction: Severe acute respiratory syndrome (SARS) caused large outbreaks of atypical pneumonia in 2003, with the largest localized outbreak occurring in Beijing, China. Lymphopenia was prominent amongst the laboratory abnormalities reported in acute SARS. Methods: The effect of SARS on peripheral blood lymphocytes and their subsets was examined in 271 SARS coronavirus-infected individuals. Results: There was a significant decrease in the CD45+, CD3+, CD4+, CD8+, CD19+ and CD16+/56+ cell counts over the five weeks of the SARS illness although CD4+/CD8+ ratios did not change significantly. The lymphopenia was prolonged, reaching a nadir during days 7-9 in the second week of illness before returning towards normal after five weeks, with the lowest mean CD4+ cell count of 317 cells x 10⁶/L at day 7, and CD8+ cell count of 239 cells × 10⁶/L at day 8. Patients with more severe clinical illness, or patients who died, had significantly more profound CD4+ and CD8+ lymphopenia. Discussion: Lymphopenia is a prominent part of SARS-CoV infection and lymphocyte counts may be useful in predicting the severity and clinical outcomes. Possible reasons for the SARS-associated lymphopenia may be direct infection of lymphocytes by SARS-CoV, lymphocyte sequestration in the lung or cytokine-mediated lymphocyte trafficking. There may also be immune-mediated lymphocyte destruction, bone marrow or thymus suppression, or apoptosis.

Affiliations:

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Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Effects of severe acute respiratory syndrome (SARS) coronavirus infection on peripheral blood lymphocytes and their subsets</title>
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<series><title level="j" type="main">International journal of infectious diseases</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Bacteremia</term>
<term>Cell subpopulation</term>
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<term>Lymphocyte</term>
<term>Lymphocytopenia</term>
<term>Severe acute respiratory syndrome</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term>
<term>Bactériémie</term>
<term>Lymphopénie</term>
<term>Sous population cellulaire</term>
<term>Lymphocyte</term>
<term>Coronavirus</term>
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<front><div type="abstract" xml:lang="en">Introduction: Severe acute respiratory syndrome (SARS) caused large outbreaks of atypical pneumonia in 2003, with the largest localized outbreak occurring in Beijing, China. Lymphopenia was prominent amongst the laboratory abnormalities reported in acute SARS. Methods: The effect of SARS on peripheral blood lymphocytes and their subsets was examined in 271 SARS coronavirus-infected individuals. Results: There was a significant decrease in the CD45+, CD3+, CD4+, CD8+, CD19+ and CD16+/56+ cell counts over the five weeks of the SARS illness although CD4+/CD8+ ratios did not change significantly. The lymphopenia was prolonged, reaching a nadir during days 7-9 in the second week of illness before returning towards normal after five weeks, with the lowest mean CD4+ cell count of 317 cells x 10<sup>6</sup>
/L at day 7, and CD8+ cell count of 239 cells × 10<sup>6</sup>
/L at day 8. Patients with more severe clinical illness, or patients who died, had significantly more profound CD4+ and CD8+ lymphopenia. Discussion: Lymphopenia is a prominent part of SARS-CoV infection and lymphocyte counts may be useful in predicting the severity and clinical outcomes. Possible reasons for the SARS-associated lymphopenia may be direct infection of lymphocytes by SARS-CoV, lymphocyte sequestration in the lung or cytokine-mediated lymphocyte trafficking. There may also be immune-mediated lymphocyte destruction, bone marrow or thymus suppression, or apoptosis.</div>
</front>
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<affiliations><list><country><li>Australie</li>
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<country name="Australie"><noRegion><name sortKey="Dwyer, Dominic E" sort="Dwyer, Dominic E" uniqKey="Dwyer D" first="Dominic E." last="Dwyer">Dominic E. Dwyer</name>
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Effects of severe acute respiratory syndrome (SARS) coronavirus infection on peripheral blood lymphocytes and their subsets

Effects of severe acute respiratory syndrome (SARS) coronavirus infection on peripheral blood lymphocytes and their subsets

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri